Mouse Anti-Human CD62P Antibody (S-921-3)

產(chǎn)品型號(hào)：S0B0580

更新時(shí)間：2025-07-11

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD62P is a type-1 transmembrane protein that in humans is encoded by the SELP gene. It functions as a cell adhesion molecule （CAM） on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. CD62P plays an essential role in the initial recruitment of leukocytes （white blood cells） to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, CD62P moves from an internal cell location to the endothelial cell surface. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. CD62P has a functional role in tumour metastasis similar to E-selectin. CD62P is expressed on the surface of both stimulated endothelial cells and activated platelets, and helps cancer cells invade into the bloodstream for metastasis and provides local multiple growth factors, respectively.

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