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S0B0923Mouse Anti-Human CD28 Antibody (S-R495-2)
產(chǎn)品型號:S0B0923
更新時間:2025-07-11
廠商性質(zhì):生產(chǎn)廠家
訪問量:33
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CD28 is a key costimulatory receptor predominantly expressed on T cells, which plays an essential role in T cell activation, proliferation, and survival. Upon binding to its ligands CD80 (B7-1) and CD86 (B7-2) expressed on antigen-presenting cells, CD28 provides a secondary signal that amplifies the initial T cell receptor engagement with the antigen. This costimulation is crucial for preventing T cell anergy and for the full execution of immune responses, including the production of cytokines and the development of memory T cells. CD28 also contributes to the induction and maintenance of regulatory T cells, and its signaling involves the activation of multiple downstream pathways, including the PI3K-AKT axis, which is important for cell metabolism and survival.
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