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當(dāng)前位置:首頁產(chǎn)品中心抗體/抗原流式抗體S0B0923Mouse Anti-Human CD28 Antibody (S-R495-2)

Mouse Anti-Human CD28 Antibody (S-R495-2)
產(chǎn)品簡介:

Mouse Anti-Human CD28 Antibody (S-R495-2)

產(chǎn)品型號:S0B0923

更新時間:2025-07-11

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CD28 is a key costimulatory receptor predominantly expressed on T cells, which plays an essential role in T cell activation, proliferation, and survival. Upon binding to its ligands CD80 (B7-1) and CD86 (B7-2) expressed on antigen-presenting cells, CD28 provides a secondary signal that amplifies the initial T cell receptor engagement with the antigen. This costimulation is crucial for preventing T cell anergy and for the full execution of immune responses, including the production of cytokines and the development of memory T cells. CD28 also contributes to the induction and maintenance of regulatory T cells, and its signaling involves the activation of multiple downstream pathways, including the PI3K-AKT axis, which is important for cell metabolism and survival.

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