FITC Rat Anti-Mouse F4/80 Antibody (S-R537)

產(chǎn)品型號(hào)：S0B5113

更新時(shí)間：2025-07-12

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

F4/80, also known as EGF-like module-containing mucin-like hormone receptor-like 1 （EMR1）, is a cell surface glycoprotein that is a member of the EGF-TM7 protein family. It is primarily used as a marker for mature macrophages in mice and shows significant expression changes during the maturation and activation of these cells. F4/80 is expressed on various mature macrophage populations, including Kupffer cells, Langerhans cells, microglia, and macrophages located in the peritoneum, intestinal lamina propria, splenic red pulp, lung, thymus, and bone marrow stroma. This antigen is encoded by the Adgre1 gene, which is a seven transmembrane G protein-coupled receptor with an extracellular domain containing repeated Epidermal Growth Factor （EGF）-like calcium binding domains. The F4/80 antigen is not only crucial for the phenotypic characterization of macrophages but also plays a role in immune regulation, as indicated by studies showing its necessity for inducing CD8+ regulatory T cells responsible for peripheral immune tolerance.

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