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產(chǎn)品中心抗體/抗原流式抗體S0B5223FITC Rabbit Anti-Human CD200 Antibody (S-1008-60)
產(chǎn)品型號：S0B5223
更新時間：2025-07-12
廠商性質(zhì)：生產(chǎn)廠家
訪問量：27
服務熱線15855403091
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相關文章
CD200, also known as OX-2 membrane glycoprotein, is a type I transmembrane protein encoded by the CD200 gene and belongs to the immunoglobulin superfamily. It is primarily expressed on various cell types, including immune cells, neuronal cells, and some non-hematopoietic cells. CD200 plays a crucial role in immune regulation by interacting with its receptor, CD200R, which is mainly expressed on myeloid cells, microglia, and activated T cells. This interaction generates inhibitory signals that suppress immune responses, such as reducing the production of inflammatory cytokines like IL-2 and IFN-γ, and promoting the expansion of regulatory T cells. In addition, CD200 is involved in maintaining immune tolerance and preventing autoimmune diseases. However, its expression on tumor cells can lead to immune evasion by inhibiting antitumor T-cell responses. Therefore, CD200 is considered a potential target for cancer immunotherapy and the treatment of inflammatory and autoimmune diseases.
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