FITC Mouse Anti-Human/Mouse ZAP-70 Antibody (S-R678)

產(chǎn)品型號：S0B5435

更新時間：2025-07-13

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

ZAP-70 （Zeta-chain-associated protein kinase 70） is a cytoplasmic protein tyrosine kinase that plays a crucial role in T cell receptor （TCR） signaling and is essential for T cell activation and development. It is primarily expressed in T cells, natural killer cells, and a subset of B cells. When the TCR binds to an antigen, the tyrosine kinase Lck is activated, phosphorylating the immunoreceptor tyrosine-based activation motifs （ITAMs） on the CD3 complex. These phosphorylated ITAMs serve as docking sites for ZAP-70, which is then activated and phosphorylates downstream molecules such as the linker for activation of T cells （LAT） and the SH2-domain-containing leukocyte protein of 76 kDa （SLP-76）. This cascade of events leads to T cell activation, proliferation, and differentiation. In addition, ZAP-70 expression in B cells is associated with chronic lymphocytic leukemia （CLL）, making it a potential biomarker and therapeutic target.

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