Rat Anti-Mouse CD22 Antibody (S-R669)

產(chǎn)品型號：S0B5483

更新時間：2025-07-13

廠商性質(zhì)：生產(chǎn)廠家

訪問量：30

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

CD22, also known as cluster of differentiation 22, is a 140 kDa type I transmembrane glycoprotein and a member of the Siglec （sialic acid-binding immunoglobulin-like lectin） family. It is predominantly expressed on the surface of mature B cells and to a lesser extent on some immature B cells. The extracellular domain of CD22 consists of seven immunoglobulin-like domains, while its cytoplasmic tail contains conserved tyrosine motifs, including immunoreceptor tyrosine-based inhibitory motifs （ITIMs）, which play a crucial role in inhibiting B cell receptor （BCR） signaling. CD22 functions as a negative regulator of B cell activation, helping to prevent overactivation of the immune system and the development of autoimmune diseases. Additionally, it is involved in B cell trafficking and maintaining peripheral B cell tolerance. CD22's interaction with sialic acid-containing molecules on various cell types allows it to modulate B cell responses and maintain immune homeostasis.

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