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產(chǎn)品中心抗體/抗原流式抗體S0B5521Rabbit Anti-FMC63 Antibody (S-2163-77)
產(chǎn)品型號：S0B5521
更新時間：2025-07-13
廠商性質：生產(chǎn)廠家
訪問量：158
服務熱線15855403091
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相關文章
FMC63 scFv （single-chain variable fragment） is a recombinant protein derived from the variable regions （VH and VL） of the anti-CD19 monoclonal antibody FMC63, linked by a flexible peptide spacer （e.g., （Gly?Ser）?）. It specifically binds to the B-cell surface antigen CD19 with high affinity （KD ~1-10 nM） and is a key targeting component in FDA-approved CAR-T therapies, such as Kymriah?. The humanized FMC63 scFv retains potent antigen recognition while minimizing immunogenicity, making it highly effective in treating B-cell malignancies, including acute lymphoblastic leukemia （ALL） and non-Hodgkin lymphoma （NHL）. Ongoing research focuses on optimizing its affinity, stability, and functionality to enhance the safety and efficacy of CAR-T cell therapies.
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