MUC4 Recombinant Rabbit mAb (SDT-R228)

產(chǎn)品型號(hào)：S0B2240

更新時(shí)間：2025-07-13

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

Mucin 4 （MUC4）?is a highly glycosylated type I transmembrane glycoprotein. Normally acts as barrier to apical surface of epithelial cells, playing a protective and regulatory role. MUC4 expression is erroneous in many carcinomas and sarcomas, including sclerosing epithelioid fibrosarcoma?and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers.?MUC4 can serve as a ligand for the oncogenic receptor ErbB2 and a modulator of its phosphorylation and signaling. MUC4 is frequently aberrantly expressed in epithelial tumors and can promote tumor growth and metastasis.

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