Estrogen Receptor α Recombinant Rabbit mAb (SDT-10001)

產(chǎn)品型號：S0B0002E

更新時間：2025-07-13

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

Estrogen receptor （ER） belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the Cterminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 （E2）, on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.
Studies have shown ER α is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas.
Studies with immunohistochemical assay show that positive steroid hormone status has predicted favourable overall, survival, independently of hormonal treatment. Secondly, ER α can be used as a tumour marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas

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