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當(dāng)前位置:首頁產(chǎn)品中心抗體/抗原功能性抗體S0B1073Invivo Anti-Mouse CD366 (TIM-3) Recombinant mAb

Invivo Anti-Mouse CD366 (TIM-3) Recombinant mAb
產(chǎn)品簡介:

Invivo Anti-Mouse CD366 (TIM-3) Recombinant mAb

產(chǎn)品型號:S0B1073

更新時(shí)間:2025-07-14

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TIM-3 (T cell immunoglobulin and mucin domain-containing protein 3), also known as HAVCR2, is a crucial immune checkpoint molecule that is extensively expressed on various immune cells, including Th1, Th17, Treg, dendritic cells, monocytes, macrophages, and NK cells. The role of TIM-3 in the tumor immune microenvironment is particularly significant, as it is highly expressed on tumor-infiltrating CD8+ T cells and regulatory T cells (Tregs), and is co-expressed with PD-1, participating in the regulation of tumor immune evasion and T cell exhaustion. TIM-3 exerts its immune suppressive function by binding to its ligands, which include galectin-9 (Gal-9), phosphatidylserine (PtdSer), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1), and high mobility group box 1 (HMGB1). These interactions lead to Th1 cell apoptosis, T cell exhaustion, and immune suppression, thereby facilitating tumor cells to evade immune surveillance. In cancer treatment strategies, TIM-3 has emerged as a promising target. Furthermore, the expression level of TIM-3 correlates with poor prognosis in certain types of cancer, making it a potential prognostic biomarker.

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