BTK Recombinant Rabbit mAb (SDT-2105-37)

產(chǎn)品型號：S0B2376

更新時間：2025-07-15

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

Bruton's tyrosine kinase （BTK） is a non-receptor tyrosine kinase that plays a crucial role in B-cell development and function. It is encoded by the BTK gene and consists of five distinct structural domains, including a kinase domain. BTK is essential for transmitting signals from B-cell antigen receptors, leading to processes like calcium mobilization and B-cell maturation. Mutations in the BTK gene can cause X-linked agammaglobulinemia （XLA）, an immunodeficiency characterized by a lack of mature B cells and antibodies. In addition to its role in B cells, BTK is also involved in mast cell activation and has been implicated in various cancers, where its abnormal activation can lead to uncontrolled B-cell proliferation. Due to its involvement in B-cell signaling and cancer, BTK has become an important target for therapeutic interventions.

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