Alexa Fluor? 647 Mouse Anti-Mouse LAP (TGF-β1) Antibody (S-R680)

產(chǎn)品型號(hào)：S0B5424

更新時(shí)間：2025-07-13

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

TGF-β1 （Transforming Growth Factor-beta 1） is a multifunctional cytokine belonging to the TGF-β superfamily, playing a pivotal role in cell proliferation, differentiation, apoptosis, immune regulation, extracellular matrix formation, and tissue repair. Synthesized as an inactive precursor, it undergoes proteolytic activation to form a biologically active homodimer. TGF-β1 signals through binding to TGF-β receptors （Type I/II）, triggering both Smad-dependent （canonical） and Smad-independent （non-canonical, e.g., MAPK, PI3K） pathways. Critical in embryogenesis, wound healing, and fibrosis, TGF-β1 exhibits dual roles in disease—acting as a tumor suppressor early in cancer but promoting metastasis in advanced stages. Dysregulation is linked to fibrotic disorders （e.g., pulmonary fibrosis）, autoimmune diseases, and cancer progression. Its context-dependent functions （anti-inflammatory vs. pro-fibrotic/tumorigenic） are influenced by microenvironmental cues, making it a therapeutic target for fibrosis, cancer, and inflammatory conditions.

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