Beta-defensin 5 is a member of the defensin family of antimicrobial peptides that play a crucial role in the innate immune system's defense against pathogens. It is primarily expressed in the gastrointestinal tract, where it contributes to maintaining the mucosal barrier integrity and protecting against microbial invasion. Beta-defensin 5 exhibits potent antimicrobial activity against a wide range of pathogens, including bacteria, fungi, and viruses, by disrupting their cell membranes. In addition to its direct antimicrobial effects, beta-defensin 5 also plays a role in modulating immune responses, promoting wound healing, and maintaining the balance of the gut microbiota.